Immunometabolism: Oxygen sensing and cell metabolism in inflammation

Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.145

Hypoxia-inducible transcription factors (HIFs) are key mediators of several molecular and cellular responses that are activated under hypoxic conditions. New findings demonstrate an important role for the HIF system in mediating the activation and inflammatory responses of neutrophils through tight interaction with their glucose metabolism.

中文翻译：

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免疫代谢：炎症中的氧传感和细胞代谢

免疫代谢：炎症中的氧传感和细胞代谢

Nature Reviews Nephrology，在线发布：2017年10月24日；doi：10.1038 / nrneph.2017.145

低氧诱导型转录因子（HIF）是在低氧条件下激活的几种分子和细胞反应的关键介体。新发现表明，HIF系统在通过与中性粒细胞的葡萄糖代谢紧密相互作用来介导中性粒细胞的活化和炎症反应中发挥着重要作用。