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Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2017-10-23 , DOI: 10.1038/nsmb.3489 Wei Yang , Weiling Pan , Shuokai Chen , Nicola Trendel , Shutan Jiang , Feng Xiao , Manman Xue , Wei Wu , Zeli Peng , Xiaoxi Li , Hongbin Ji , Xiaolong Liu , Hai Jiang , Haopeng Wang , Hongbin Shen , Omer Dushek , Hua Li , Chenqi Xu
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2017-10-23 , DOI: 10.1038/nsmb.3489 Wei Yang , Weiling Pan , Shuokai Chen , Nicola Trendel , Shutan Jiang , Feng Xiao , Manman Xue , Wei Wu , Zeli Peng , Xiaoxi Li , Hongbin Ji , Xiaolong Liu , Hai Jiang , Haopeng Wang , Hongbin Shen , Omer Dushek , Hua Li , Chenqi Xu
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
中文翻译:
带电脂质和离子动态调节CD28构象和信号转导
带电脂质和离子动态调节CD28构象和信号转导
更新日期:2017-10-30
Nature Structural & Molecular Biology, Published online: 23 October 2017; doi:10.1038/nsmb.3489
CD28 signaling motifs are sequestered within the membrane via interactions with phospholipids. TCR activation increases the local Ca2+ concentration, which disrupts CD28-lipid interactions.
中文翻译:
带电脂质和离子动态调节CD28构象和信号转导
带电脂质和离子动态调节CD28构象和信号转导
《自然结构与分子生物学》,在线发布:2017年10月23日;doi:10.1038 / nsmb.3489
通过与磷脂的相互作用,CD28信号转导基序被隔离在膜内。TCR激活会增加局部Ca 2+浓度,从而破坏CD28-脂质相互作用。