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Targeted therapies: Understanding tumour drug addiction
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2017-11-01 , DOI: 10.1038/nrc.2017.98 Conor A. Bradley
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2017-11-01 , DOI: 10.1038/nrc.2017.98 Conor A. Bradley
Targeted therapies: Understanding tumour drug addiction
中文翻译:
靶向疗法:了解肿瘤药物成瘾
靶向疗法:了解肿瘤药物成瘾
更新日期:2017-10-30
Nature Reviews Cancer, Published online: 25 October 2017; doi:10.1038/nrc.2017.98
Kong et al. report a mechanism that underlies tumour 'drug addiction' in melanoma cell lines and mouse models involving an ERK2-dependent phenotype switch, which might have clinical implications for the use of alternating treatment strategies with targeted therapies.
中文翻译:
靶向疗法:了解肿瘤药物成瘾
靶向疗法:了解肿瘤药物成瘾
Nature Reviews Cancer,在线发表:2017年10月25日; doi:10.1038 / nrc.2017.98
孔等人。报告了一种机制,该机制是涉及ERK2依赖表型转换的黑色素瘤细胞系和小鼠模型中肿瘤“药物成瘾”的基础,这可能对靶向治疗的交替治疗策略的使用具有临床意义。