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Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2018-Feb-01 , DOI: 10.1038/ja.2017.127
Dayna Sturgess , Zongjia Chen , Jonathan M White , Mark A Rizzacasa

The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 (1) from the common d-ribose-derived acid 6 are described.

中文翻译:

角鲨烯合酶抑制剂(-)-CJ-13,982及其对映异构体的对映体全合成。

描述了由常见的d-核糖衍生的酸6合成的柠檬酸烷基酯天然产物CJ-13,982(1)的天然和非天然对映体的总合成。
更新日期:2017-10-30
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