Aminoglycoside antibiotics (AGAs) were developed at the dawn of the antibiotics era and have significantly aided in the treatment of infectious diseases. Aminoglycosides have become one of the four major types of antibiotics in use today and, fortunately, still have an important role in the clinical treatment of severe bacterial infections. In this review, the current usage, modes of action and side effects of AGAs, along with the most common bacterial resistance mechanisms, are outlined. Finally, the recent development situation and possibility of new AGAs in the 'post-antibiotic era' are considered.The Journal of Antibiotics advance online publication, 25 October 2017; doi:10.1038/ja.2017.117.

中文翻译：

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“后抗生素时代”中氨基糖苷类抗生素的目的地。

氨基糖苷类抗生素（AGAs）是在抗生素时代来临之际开发的，对治疗传染病有很大帮助。氨基糖苷类已成为当今使用的四种主要抗生素之一，幸运的是，在严重细菌感染的临床治疗中，氨基糖苷类仍具有重要作用。在这篇综述中，概述了AGA的当前用法，作用方式和副作用，以及最常见的细菌耐药机制。最后，考虑了``后抗生素时代''的最新发展状况和新AGA的可能性。《抗生素杂志》在线提前出版，2017年10月25日; doi：10.1038 / ja.2017.117。