Palladium-Catalyzed Cyclization Reaction of o-Iodoanilines, CO2, and CO: Access to Isatoic Anhydrides,ACS Catalysis

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Palladium-Catalyzed Cyclization Reaction of o-Iodoanilines, CO2, and CO: Access to Isatoic Anhydrides
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-10-27 00:00:00 , DOI: 10.1021/acscatal.7b03000
Wen-Zhen Zhang ₁ , Ning Zhang ₁ , Yu-Qian Sun ₁ , Yu-Wei Ding ₁ , Xiao-Bing Lu ₁

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Isatoic anhydrides, a class of valuable synthetic intermediates and RNA structure probing reagents, are usually prepared with highly toxic phosgene or stoichiometric oxidants. Herein we report a highly selective palladium-catalyzed cyclization reaction for the efficient synthesis of isatoic anhydrides from readily available o-iodoanilines, CO₂, and CO. The reaction proceeds under mild conditions and is redox-neutral. Both CO₂ and CO are indispensable C1 building blocks for this catalytic reaction.

中文翻译：

邻位碘苯胺，CO ₂和CO的钯催化环化反应：获得等位酸酐

通常使用高毒性的光气或化学计量的氧化剂来制备一类酸酐，一类有价值的合成中间体和RNA结构探测试剂。本文中，我们报道了一种高度选择性的钯催化环化反应，用于从容易获得的邻碘代苯胺，CO ₂和CO有效合成isatoic酸酐。该反应在温和的条件下进行，并且是氧化还原中性的。对于该催化反应，CO ₂和CO都是不可或缺的C1结构单元。

更新日期：2017-10-28

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