Batelaan and colleagues examine risk of relapse in people with remitted anxiety disorders after tapering of antidepressant medication. In their meta-analysis of 28 studies, comprising 5233 participants followed for up to 12 months, a higher risk of relapse was found after antidepressant medication cessation than with continuation (summary odds ratio [OR] 3·11, 95% CI 2·48–3·89; I²=8·07%). Additionally, analysis of 11 studies (n=3002) suggested that discontinuation of antidepressant medication led to relapse occurring sooner than in people who continued medication (summary hazard ratio [HR] 3·63, 95% CI 2·58–5·10; I²=0%).

中文翻译：

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研究综述

Batelaan和他的同事研究了逐渐减少的抗抑郁药物治疗后，缓解的焦虑症患者复发的风险。在他们对28项研究的荟萃分析中，包括5233名参与者，随访时间长达12个月，发现抗抑郁药停药后复发的风险高于继续治疗（总比值比[OR] 3·11，95％CI 2·48 –3·89；I ² = 8·07％）。此外，对11项研究（n = 3002）的分析表明，停止服用抗抑郁药比复发的人更快地复发（总危险比[HR] 3·63，95％CI 2·58-5·10；我² = 0％）。