Background

In cross-sectional studies triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease.

Objectives

We investigated the association between prenatal and early-life triclosan and paraben exposure and childhood allergic disease in a prospective longitudinal study.

Methods

Subjects were enrollees in the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben, and propyl paraben concentrations were quantified in maternal plasma samples pooled from the first and third trimesters and urine samples from children at age 3 or 4 years. Outcomes were parental report of physician-diagnosed asthma or recurrent wheezing and allergic sensitization to food or environmental antigens based on serum specific IgE levels at age 3 years in high-risk children.

Results

The analysis included 467 mother-child pairs. Overall, there were no statistically significant associations of maternal plasma or child urine triclosan or paraben concentrations with asthma or recurrent wheeze or food or environmental sensitization at age 3 years. A trend toward an inverse association between triclosan and paraben exposure and allergic sensitization was observed. There was evidence of effect measure modification by sex, with higher odds of environmental sensitization associated with increasing paraben concentrations in male compared with female subjects.

Conclusions

We did not identify a consistent association between prenatal and early-life triclosan or paraben concentrations and childhood asthma, recurrent wheeze, or allergic sensitization in the overall study population. The differential effects of triclosan or paraben exposure on allergic sensitization by sex observed in this study warrant further exploration.

中文翻译：

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产前和生命早期的三氯生和对羟基苯甲酸酯暴露和过敏结果

背景

在横断面研究中，三氯生和对羟基苯甲酸酯，个人护理用品和其他产品中普遍存在的成分与过敏性疾病有关。

目标

在一项前瞻性纵向研究中，我们调查了产前和生命早期的三氯生，对羟基苯甲酸酯暴露与儿童过敏性疾病之间的关联。

方法

受试者为维生素D减少产前哮喘试验的参与者。从孕早期和孕中期收集的孕妇血浆样品以及3岁或4岁儿童的尿液样品中定量测定三氯生，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的浓度。结局是父母根据高风险儿童3岁时的血清特异性IgE水平对医师诊断出的哮喘或反复喘息和对食物或环境抗原过敏的报告。

结果

分析包括467对母子对。总体而言，在3岁时，母亲血浆或儿童尿液中的三氯生或对羟基苯甲酸酯浓度与哮喘或反复喘鸣或食物或环境致敏性之间无统计学意义的关联。观察到三氯生和对羟基苯甲酸酯接触与过敏性致敏之间呈负相关的趋势。有证据表明，按性别对效果量度进行了修改，与女性相比，男性中对羟基苯甲酸酯浓度升高的环境致敏几率更高。

结论

在整个研究人群中，我们没有发现产前和生命早期的三氯生或对羟基苯甲酸酯浓度与儿童哮喘，复发性喘息或过敏性致敏之间的一致性。在这项研究中观察到的三氯生或对羟基苯甲酸酯暴露对性别过敏致敏的差异作用值得进一步探讨。