Cover Feature: A Systematic Structure–Activity Study of a New Type of Small Peptidic Transfection Vector Reveals the Importance of a Special Oxo‐Anion‐Binding Motif for Gene Delivery (ChemBioChem 22/2017),ChemBioChem

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Cover Feature: A Systematic Structure–Activity Study of a New Type of Small Peptidic Transfection Vector Reveals the Importance of a Special Oxo‐Anion‐Binding Motif for Gene Delivery (ChemBioChem 22/2017)
ChemBioChem ( IF 2.6 ) Pub Date : 2017-10-27 , DOI: 10.1002/cbic.201700567
Sandra Junghänel ₁ , Sarah Karczewski ₂ , Sandra Bäcker ₂ , Shirley K. Knauer ₂ , Carsten Schmuck ₁

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The cover feature shows that three‐armed cationic peptide ligands are efficient gene transfection vectors. However, only when they contain an artificial oxoanion binding site, the GCP group, in their arms. Ligands with arginine, lysine or histidine instead show no transfection. In our paper we analyse the reason for this behaviour. More information can be found in the full paper by C. Schmuck et al. on page 2268 in Issue 22, 2017 (DOI: 10.1002/cbic.201700433).

中文翻译：

封面人物：新型小肽转染载体的系统结构-活性研究揭示了特殊的氧阴离子结合基序对于基因传递的重要性（ChemBioChem 22/2017）

掩盖特征表明三臂阳离子肽配体是有效的基因转染载体。但是，仅当它们的臂中含有人工氧阴离子结合位点时，即GCP基团。相反，具有精氨酸，赖氨酸或组氨酸的配体不显示转染。在我们的论文中，我们分析了这种行为的原因。有关更多信息，请参见C. Schmuck等人的全文。就在第22期，2017年2268页（：10.1002 / cbic.201700433 DOI）。

更新日期：2017-10-27

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