Cover Feature: Synthetic Modular Antibody Construction by Using the SpyTag/SpyCatcher Protein‐Ligase System (ChemBioChem 22/2017),ChemBioChem

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Cover Feature: Synthetic Modular Antibody Construction by Using the SpyTag/SpyCatcher Protein‐Ligase System (ChemBioChem 22/2017)
ChemBioChem ( IF 2.6 ) Pub Date : 2017-10-26 , DOI: 10.1002/cbic.201700569
Md Kausar Alam ₁ , Carolina Gonzalez ₁ , Wayne Hill ₁ , Ayman El-Sayed ₁ , Humphrey Fonge ₂ , Kris Barreto ₁ , C. Ronald Geyer ₁

Affiliation

The cover feature picture shows a molecular toolkit for constructing synthetic antibodies. A new modular approach to post‐translationally assemble antibody‐like “devices” from well‐behaved antibody domains or “parts” by using the Spytag/SpyCatcher protein ligase system is demonstrated. This toolkit allows antibody parts to be assembled in configurations that are not possible with genetic engineering approaches. We predict that this modular approach will create optimized antibody devices in less time and at reduced costs. More information can be found in the communication by C. R. Geyer et al. on page 2217 in Issue 22, 2017 (DOI: 10.1002/cbic.201700411).

中文翻译：

封面文章：使用SpyTag / SpyCatcher蛋白-连接酶系统构建合成模块化抗体（ChemBioChem 22/2017）

封面特征图片显示了用于构建合成抗体的分子工具包。演示了一种新的模块化方法，该方法通过使用Spytag / SpyCatcher蛋白连接酶系统从行为良好的抗体域或“部分”进行翻译后组装抗体样“装置”。该工具包允许抗体零件以基因工程方法无法实现的配置进行组装。我们预测，这种模块化方法将在更短的时间内以降低的成本创建优化的抗体设备。可以在C. R. Geyer等人的来文中找到更多信息。就在第22期，2017年2217页（：10.1002 / cbic.201700411 DOI）。

更新日期：2017-10-26

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