Multi-electrode recordings in the non-human primate provide a critical method for measuring the widely distributed activity patterns that underlie brain function. However, common techniques rely on small, often immovable arrays, or microdrives, that are only capable of manipulating a small number of closely spaced probes. These techniques restrict the number of cortical areas that can be simultaneously sampled and are typically not capable of reaching subcortical targets. To overcome these limitations, we developed a large-scale, semi-chronic microdrive recording system with up to 256 independently movable microelectrodes spanning an entire cerebral hemisphere. The microdrive system is hermetically sealed, free of internal connecting wires, and has been used to simultaneously record from up to 37 cortical and subcortical areas in awake behaving monkeys for up to 9 months. As a proof of principle, we demonstrate the capability of this technique to address network-level questions using a graph theoretic analysis of functional connectivity data.

中文翻译：

---

用于非人类灵长类动物的大型半慢性微驱动器记录系统。

非人类灵长类动物中的多电极记录提供了一种重要的方法，可用来测量构成大脑功能基础的广泛分布的活动模式。但是，常见技术依赖于小型的，通常是不可移动的阵列或微驱动器，它们仅能够操纵少量紧密间隔的探针。这些技术限制了可以同时采样的皮层区域的数量，并且通常无法达到皮层下的目标。为了克服这些局限性，我们开发了一种大型半同步微驱动记录系统，该系统具有多达256个可独立移动的微电极，横跨整个大脑半球。微驱动器系统是密封的，没有内部连接线，并已被用来同时记录清醒的猴子中多达37个皮质和皮质下区域，长达9个月。作为原理的证明，我们使用功能连接数据的图论分析来证明该技术解决网络级问题的能力。