Highly versatile BODIPY dyes proved themselves to be very useful as photosensitizers. These dyes can be derivatized to absorb essentially anywhere in the visible the near IR region of the spectrum. As a result of their diverse reactivity, singlet oxygen generation efficiency can be modulated very precisely, leading to a number of selective photosensitizers for photodynamic therapy. Among the biologically relevant modulators, glutathione concentration and pH received particular attention. In this review, we highlight modulatable BODIPY-based photodynamic photosensitizers, and various synthetically useful chemical reactions triggered by singlet oxygen and other reactive oxygen species generated by BODIPY-based photosensitizers.

用途广泛的BODIPY染料证明自己作为光敏剂非常有用。可以将这些染料衍生化，以吸收可见光谱中近红外区域中的任何地方。由于它们具有多种反应性，因此可以非常精确地调节单线态氧的产生效率，从而导致了许多用于光动力疗法的选择性光敏剂。在生物学相关的调节剂中，谷胱甘肽浓度和pH受到特别关注。在本文中，我们重点介绍了可调节的基于BODIPY的光敏光敏剂，以及由基于BODIPY的光敏剂产生的单线态氧和其他活性氧引发的各种合成有用的化学反应。