Total synthesis of strictamine: a tutorial for novel and efficient synthesis,Organic Chemistry Frontiers

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Total synthesis of strictamine: a tutorial for novel and efficient synthesis
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7qo00837f
Chao Wang _{1,

2,

3,

4,

5} , Shiju Zhang _{4,

6,

7,

8} , Yan Wang _{1,

2,

3,

4,

5} , Sha-Hua Huang _{4,

6,

7,

8} , Ran Hong _{1,

2,

3,

4,

5}

Affiliation

When teaching synthetic design in the classroom, the novelty and efficiency of the overall synthetic route are the key values being imparted to the younger generation of synthetic chemists. The creative synthetic design is of great interest to graduate students who are entering into this exciting field for the first time. Strictamine, an akuammiline alkaloid, bears a congested cage-like structure and has interesting biological activities. Numerous attempts have been made toward the total synthesis of this compound since its discovery five decades ago. The synthesis was not completed until last year when synthetic chemists began to apply novel ring construction strategies. In 2016, two research groups reported the total syntheses of strictamine and four reported the formal syntheses. In this Highlight, the synthesis of strictamine is used as a tutorial case to illustrate novelty and efficiency in total synthesis.

中文翻译：

严格胺的全合成：新颖有效合成的指南

在课堂上教授合成设计时，整体合成路线的新颖性和效率是赋予年轻一代合成化学家的关键价值。首次进入这个令人兴奋的领域的研究生对创意的合成设计非常感兴趣。曲胺，一种阿卡米林生物碱，具有拥挤的笼状结构，并具有有趣的生物学活性。自从五十年前发现该化合物以来，已经进行了许多尝试以实现全合成。直到去年合成化学家开始应用新的环构建策略时，合成才完成。2016年，两个研究小组报告了严格胺的全部合成，四个报告了正式合成。在本集锦中，

更新日期：2017-10-26

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