A new method to construct 4-hydroxyalkyl-quinoline derivatives is described via Cu(I) and Au(I) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic alkynes, respectively. The three-component cascade reaction provides an efficient approach for easy access to various new quinoline-based derivatives and quinoline containing an aliphatic chain substituent at the 4-position with high yields.

中文翻译：

---

使用CuCl / AuCl作为连续催化剂通过三组分反应合成取代的4-羟烷基喹啉衍生物

通过Cu（I）和Au（I）分别用醛衍生物和脂族炔烃依次催化苯胺的环化反应，描述了一种构建4-羟烷基喹啉衍生物的新方法。三组分级联反应提供了一种高效途径，可以轻松地高产率地获得各种新的基于喹啉的衍生物和在4-位含有脂族链取代基的喹啉。