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Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits
Nature Medicine ( IF 82.9 ) Pub Date : 2017-10-16 , DOI: 10.1038/nm.4413 Jason C You , Kavitha Muralidharan , Jin W Park , Iraklis Petrof , Mark S Pyfer , Brian F Corbett , John J LaFrancois , Yi Zheng , Xiaohong Zhang , Carrie A Mohila , Daniel Yoshor , Robert A Rissman , Eric J Nestler , Helen E Scharfman , Jeannie Chin
Nature Medicine ( IF 82.9 ) Pub Date : 2017-10-16 , DOI: 10.1038/nm.4413 Jason C You , Kavitha Muralidharan , Jin W Park , Iraklis Petrof , Mark S Pyfer , Brian F Corbett , John J LaFrancois , Yi Zheng , Xiaohong Zhang , Carrie A Mohila , Daniel Yoshor , Robert A Rissman , Eric J Nestler , Helen E Scharfman , Jeannie Chin
Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits
中文翻译：
ΔFosB对海马calbindin-D28k的表观遗传抑制可导致癫痫发作相关的认知功能障碍
ΔFosB对海马calbindin-D28k的表观遗传抑制可导致癫痫发作相关的认知功能障碍
更新日期：2017-10-25
Nature Medicine, Published online: 16 October 2017; doi:10.1038/nm.4413
In rodent models of Alzheimer's disease (AD) and epilepsy, seizure-dependent induction of ΔFosB results in epigenetic silencing of calbindin. Hippocampal inhibition of ΔFosB or elevation of calbindin rescues spatial memory deficits in mouse models of AD.
中文翻译：
ΔFosB对海马calbindin-D28k的表观遗传抑制可导致癫痫发作相关的认知功能障碍
ΔFosB对海马calbindin-D28k的表观遗传抑制可导致癫痫发作相关的认知功能障碍
《自然医学》（Nature Medicine），在线发布：2017年10月16日; doi：10.1038 / nm.4413
在阿尔茨海默氏病（AD）和癫痫的啮齿动物模型中，依赖癫痫发作的ΔFosB诱导导致calbindin的表观遗传沉默。海马对ΔFosB的抑制或钙结合蛋白的升高可挽救AD小鼠模型的空间记忆缺陷。
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