Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

Nature Medicine, Published online: 9 October 2017; doi:10.1038/nm.4415

Microenvironmental pressures in glioblastoma select for glioma stem cells (GSCs) subpopulations that are maintained through preferential activation of BMI1 and EZH2 in different niches. Given the high degree of intratumor heterogeneity, combined pharmacological inhibition of Polycomb repressive complexes targets proneural and mesenchynmal GSCs and expands lifespan in mice, warranting the therapeutic evaluation of this approach in patients with glioblastoma.

中文翻译：

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通过联合抑制BMI1和EZH2靶向神经胶质瘤干细胞

通过联合抑制BMI1和EZH2靶向神经胶质瘤干细胞

《自然医学》（Nature Medicine），在线发布：2017年10月9日; doi：10.1038 / nm.4415

胶质母细胞瘤中的微环境压力选择了通过优先激活BMI1和EZH2在不同位境中得以维持的神经胶质瘤干细胞（GSC）亚群。鉴于高度的肿瘤内异质性，对Polycomb阻抑复合物的联合药理抑制作用靶向前和间叶GSC，并延长了小鼠的寿命，从而保证了这种方法对胶质母细胞瘤患者的治疗性评价。