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Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-16 , DOI: 10.1038/ncb3625 Allison L. Boyd , Jennifer C. Reid , Kyle R. Salci , Lili Aslostovar , Yannick D. Benoit , Zoya Shapovalova , Mio Nakanishi , Deanna P. Porras , Mohammed Almakadi , Clinton J. V. Campbell , Michael F. Jackson , Catherine A. Ross , Ronan Foley , Brian Leber , David S. Allan , Mitchell Sabloff , Anargyros Xenocostas , Tony J. Collins , Mickie Bhatia
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-16 , DOI: 10.1038/ncb3625 Allison L. Boyd , Jennifer C. Reid , Kyle R. Salci , Lili Aslostovar , Yannick D. Benoit , Zoya Shapovalova , Mio Nakanishi , Deanna P. Porras , Mohammed Almakadi , Clinton J. V. Campbell , Michael F. Jackson , Catherine A. Ross , Ronan Foley , Brian Leber , David S. Allan , Mitchell Sabloff , Anargyros Xenocostas , Tony J. Collins , Mickie Bhatia
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
中文翻译：
急性髓性白血病通过损害脂肪细胞的骨髓生境来破坏内源性骨髓红细胞生成
急性髓性白血病通过损害脂肪细胞的骨髓生境来破坏内源性骨髓红细胞生成
更新日期：2017-10-25
Nature Cell Biology, Published online: 16 October 2017; doi:10.1038/ncb3625
Boyd et al. monitored the effects of patient-derived acute myeloid leukaemia (AML) cells on human HSPCs in vivo and found that AML impairs bone marrow adipocyte differentiation, and this in turn impedes healthy endogenous haematopoiesis.
中文翻译：
急性髓性白血病通过损害脂肪细胞的骨髓生境来破坏内源性骨髓红细胞生成
急性髓性白血病通过损害脂肪细胞的骨髓生境来破坏内源性骨髓红细胞生成
《自然细胞生物学》（Nature Cell Biology），在线发布：2017年10月16日; doi：10.1038 / ncb3625
博伊德（Boyd）等人。监测患者源性急性髓细胞白血病（AML）细胞对人HSPC的体内影响，发现AML损害了骨髓脂肪细胞的分化，进而阻碍了健康的内源性造血功能。
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