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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-16 , DOI: 10.1038/ncb3626 Beatrice Rondinelli , Ewa Gogola , Hatice Yücel , Alexandra A. Duarte , Marieke van de Ven , Roxanne van der Sluijs , Panagiotis A. Konstantinopoulos , Jos Jonkers , Raphaël Ceccaldi , Sven Rottenberg , Alan D. D’Andrea
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-16 , DOI: 10.1038/ncb3626 Beatrice Rondinelli , Ewa Gogola , Hatice Yücel , Alexandra A. Duarte , Marieke van de Ven , Roxanne van der Sluijs , Panagiotis A. Konstantinopoulos , Jos Jonkers , Raphaël Ceccaldi , Sven Rottenberg , Alan D. D’Andrea
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
中文翻译:
EZH2通过组蛋白H3三甲基化募集MUS81来促进停滞的复制叉的降解
EZH2通过组蛋白H3三甲基化募集MUS81来促进停滞的复制叉的降解
更新日期:2017-10-25
Nature Cell Biology, Published online: 16 October 2017; doi:10.1038/ncb3626
Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 contributes to PARPi resistance in BRCA2-deficient tumours.
中文翻译:
EZH2通过组蛋白H3三甲基化募集MUS81来促进停滞的复制叉的降解
EZH2通过组蛋白H3三甲基化募集MUS81来促进停滞的复制叉的降解
《自然细胞生物学》(Nature Cell Biology),在线发布:2017年10月16日; doi:10.1038 / ncb3626
Rondinelli等。结果表明,在停滞的复制叉中,EZH2介导的H3K27me3募集了MUS81核酸酶,以促进叉的降解。EZH2的丢失有助于BRCA2缺乏肿瘤中的PARPi抗性。