Facile synthesis of 1-aminoindoles via Rh(III)-catalysed intramolecular three-component annulation,Organic Chemistry Frontiers

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Facile synthesis of 1-aminoindoles via Rh(III)-catalysed intramolecular three-component annulation
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1039/c7qo00541e
Zi Yang _{1,

2,

3,

4,

5} , Xing Lin _{1,

2,

3,

4,

5} , Lianhui Wang _{1,

2,

3,

4,

5} , Xiuling Cui _{1,

2,

3,

4,

5}

Affiliation

The facile synthesis of various 1-aminoindoles from readily available aryl hydrazines, diazo compounds and ketones via rhodium catalysed C–H activation has been developed. The reaction was carried out under mild reaction conditions using hydrazone as a directing group, which was formed by the in situ condensation of hydrazines and ketones. This protocol exhibits a broad substrate scope and step economy, releasing N₂ and H₂O as the byproducts, obviating the need for external oxidants and pre-functionalized substrates.

中文翻译：

通过Rh（III）催化的分子内三组分环化反应轻松合成1-氨基吲哚

已经开发了通过铑催化的C–H活化从易得的芳基肼，重氮化合物和酮轻松合成各种1-氨基吲哚的方法。该反应是在温和的反应条件下进行的，以为导向基团，hydr是通过肼和酮的原位缩合反应而形成的。该方案显示了广泛的底物范围和步骤经济性，释放出N ₂和H ₂ O作为副产物，从而消除了对外部氧化剂和预功能化底物的需求。

更新日期：2017-10-25

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