Rapid construction of complex tetracyclic frameworks via a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rapid construction of complex tetracyclic frameworks via a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-07-20 00:00:00 , DOI: 10.1039/c7qo00511c
Haiyu Sun _{1,

2,

3,

4,

5} , Shiyan Xu _{1,

2,

3,

4,

5} , Zhimin Xing _{1,

2,

3,

4,

5} , Lin Liu _{1,

2,

3,

4,

5} , Shangbiao Feng _{1,

2,

3,

4,

5} , Bowen Fang _{4,

5,

6,

7} , Xingang Xie _{1,

2,

3,

4,

5} , Xuegong She _{1,

2,

3,

4,

5}

Affiliation

An efficient synthesis of complex tetracyclic compounds is developed which relies on a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters. The reaction proceeds under extremely mild conditions in good to excellent yields (54%–88%) with a dr value of up to 20 : 1.

中文翻译：

通过金（I）催化的串联1，2-酰氧基迁移/ [3 + 2]环加成/ Friedel-Crafts型线性烯基酯的环化反应，快速构建复杂的四环骨架

开发了一种有效的合成复杂四环化合物的方法，该方法依赖于金（I）催化的串联1,2-酰氧基迁移/ [3 + 2]环加成/ Friedel-Crafts线性烯丙基酯的环化反应。反应在极温和的条件下以良好的产率（54％–88％）进行，dr值高达20：1。

更新日期：2017-10-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11