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Rapid construction of complex tetracyclic frameworks via a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-07-20 00:00:00 , DOI: 10.1039/c7qo00511c
Haiyu Sun 1, 2, 3, 4, 5 , Shiyan Xu 1, 2, 3, 4, 5 , Zhimin Xing 1, 2, 3, 4, 5 , Lin Liu 1, 2, 3, 4, 5 , Shangbiao Feng 1, 2, 3, 4, 5 , Bowen Fang 4, 5, 6, 7 , Xingang Xie 1, 2, 3, 4, 5 , Xuegong She 1, 2, 3, 4, 5
Affiliation  

An efficient synthesis of complex tetracyclic compounds is developed which relies on a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters. The reaction proceeds under extremely mild conditions in good to excellent yields (54%–88%) with a dr value of up to 20 : 1.

中文翻译:

通过金(I)催化的串联1,2-酰氧基迁移/ [3 + 2]环加成/ Friedel-Crafts型线性烯基酯的环化反应,快速构建复杂的四环骨架

开发了一种有效的合成复杂四环化合物的方法,该方法依赖于金(I)催化的串联1,2-酰氧基迁移/ [3 + 2]环加成/ Friedel-Crafts线性烯丙基酯的环化反应。反应在极温和的条件下以良好的产率(54%–88%)进行,dr值高达20:1。
更新日期:2017-10-25
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