Evidence suggests that cells can time-encode signals for secure transport and perception of information, and it appears that this dynamic signaling is a common principle of nature to code information in time. G-protein-coupled receptor (GPCR) signaling networks are no exception as their composition and signal transduction appear temporally flexible. In this review, we discuss the potential mechanisms by which GPCRs code biological information in time to create ‘temporal bias.’ We highlight dynamic signaling patterns from the second messenger to the receptor–ligand level and shed light on the dynamics of G-protein cycles, the kinetics of ligand–receptor interaction, and the occurrence of distinct signaling waves within the cell. A dynamic feature such as temporal bias adds to the complexity of GPCR signaling bias and gives rise to the question whether this trait could be exploited to gain control over time-encoded cell physiology.

有证据表明，细胞可以对信号进行时间编码以确保信息的安全传输和感知，并且这种动态信号似乎是及时编码信息的自然共同原理。G蛋白偶联受体（GPCR）信号网络也不例外，因为它们的组成和信号转导在时间上具有灵活性。在这篇综述中，我们讨论了GPCR及时编码生物信息以产生“时间偏差”的潜在机制。我们重点介绍了从第二信使到受体-配体水平的动态信号传导模式，并阐明了G蛋白循环的动力学，配体-受体相互作用的动力学以及细胞内独特信号传导的发生。