Background

Bioactive molecules are mostly amenable to degradation at processing, storage, and harsh digestion conditions. Hence, high-throughput encapsulation bodies must be designed in a way to protect them from destructive circumstances and to enhance their bioavailability.

Scope and approach

This review article focuses on versatile mechanisms for gelation of globular proteins and highlights the current studies on whey and soy protein hydrogels as two key animal and herbal proteins used in fabricating coating materials. Moreover, different categories of hydrogels, such as aerated hydrogels, hydrogels made from aggregated forms of proteins, hydrogels originated from food-grade materials, and hydrogels with nano scale dimensions are discussed.

Key findings and conclusions

The gelation and particulation method have dramatic effects on the liberation features as well as the bioactivity of the wrapped ingredients. Therefore, different approaches are needed to be considered in order to increase the bioavailability of nutraceuticals and drugs accommodated within protein hydrogels. Accordingly, there is a growing trend for developing innovative modes of gelation and immobilizing bioactive materials into the hydrogel network.

中文翻译：

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基于乳清和大豆蛋白的水凝胶和纳米水凝胶作为生物活性传递系统

背景

生物活性分子最易于在加工，储存和恶劣的消化条件下降解。因此，高通量封装体必须以一种保护其免受破坏性环境并提高其生物利用度的方式设计。

范围和方法

这篇综述文章重点介绍了球形蛋白凝胶化的多种机制，并着重介绍了目前对乳清和大豆蛋白水凝胶的研究，乳清蛋白和大豆蛋白水凝胶是制造涂层材料时使用的两种关键的动物和草药蛋白。此外，还讨论了不同类别的水凝胶，例如充气水凝胶，由聚集形式的蛋白质制成的水凝胶，源自食品级材料的水凝胶以及具有纳米级尺寸的水凝胶。

主要发现和结论

胶凝和颗粒化方法对包裹成分的释放特征以及生物活性具有显着影响。因此，需要考虑不同的方法，以增加蛋白质水凝胶中所含营养食品和药物的生物利用度。因此，发展凝胶化的创新模式并将生物活性材料固定到水凝胶网络中的趋势正在增长。