Cu2+-Complex of hydrophilic nitrogen-rich polymer dots applied as a new MRI contrast agent,Biomaterials Science

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Cu2+-Complex of hydrophilic nitrogen-rich polymer dots applied as a new MRI contrast agent
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-09-27 00:00:00 , DOI: 10.1039/c7bm00731k
Mengyue Hu _{1,

2,

3,

4} , Jing Chen _{1,

2,

3,

4,

5} , Jingmin Wang _{1,

2,

3,

4} , Ye Zhang _{1,

2,

3,

4} , Li Liu _{1,

2,

3,

4} , Paulo Cesar Morais _{1,

2,

3,

4,

6} , Hong Bi _{1,

2,

3,

4}

Affiliation

We report on a novel Cu²⁺-complex of nitrogen-rich polymer dots for magnetic resonance imaging (MRI). The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 °C (24 h) and used later on to fabricate a Cu²⁺-PVIm dot complex via efficient incorporation of Cu²⁺ into aqueous medium. The obtained Cu²⁺-PVIm dot complexes display relaxivity (r₁ = 1.05 mM⁻¹ s⁻¹) two times higher than Cu²⁺ in aqueous solution (r₁ = 0.43 mM⁻¹ s⁻¹) and three times higher than Cu²⁺ in aqueous solution coordinated with VIm monomers (r₁ = 0.32 mM⁻¹ s⁻¹), which show a remarkable contrast enhancement for T₁-weighted MRI while efficiently labeling MCF-7 cells and other biomedical applications.

中文翻译：

Cu 2 ⁺ -亲水性富氮聚合物点复合物作为新型MRI造影剂

我们报告了一种新型的富含氮的聚合物点的Cu ²⁺复合物，用于磁共振成像（MRI）。富含N的聚合物点是由N-乙烯基咪唑（VIm）在220°C（24 h）下通过一锅水热合成制备的，随后用于通过有效掺入Cu来制备Cu ²⁺ -PVIm点复合物²⁺到水性介质中。所获得的Cu ²⁺ -PVIm点复合物的弛豫性（r ₁ = 1.05 mM ^-1 s ^-1）是水溶液中Cu ^2+的弛豫性（r ₁ = 0.43 mM ^-1 s ^-1）的两倍。）并在与VIm单体（r ₁ = 0.32 mM ^-1 s ^-1）配比的水溶液中比Cu ²⁺高三倍，这显示出T ₁加权MRI的显着对比度增强，同时有效标记MCF-7细胞和其他生物医学应用。

更新日期：2017-10-24

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