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Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures
Advanced Materials ( IF 27.4 ) Pub Date : 2017-10-23 , DOI: 10.1002/adma.201703045
Ziguang Zhao 1 , Ruochen Fang 1 , Qinfeng Rong 1 , Mingjie Liu 1, 2
Affiliation  

In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their “soft and wet” properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited. Inspired by biological soft tissues with well‐ordered structures, researchers have increasingly investigated highly ordered nanocomposite hydrogels as functional biological engineering soft materials with unique mechanical, optical, and biological properties. These hydrogels incorporate long‐range ordered nanocomposite structures within hydrogel network matrixes. Here, the critical design criteria and the state‐of‐the‐art fabrication strategies of nanocomposite hydrogels with highly ordered structures are systemically reviewed. Then, recent progress in applications in the fields of soft actuators, tissue engineering, and sensors is highlighted. The future development and prospective application of highly ordered nanocomposite hydrogels are also discussed.

中文翻译:

具有高度有序结构的生物启发性纳米复合水凝胶

在人体中,许多具有分层有序的复合结构的软组织,例如软骨,骨骼肌,角膜和血管,具有高度各向异性的机械强度和功能,可以适应复杂的环境。在人造软材料中,水凝胶由于其“柔软和湿润”的特性,它们的生物相容性和弹性性能而类似于这些生物软组织。然而,具有无序均质结构的常规水凝胶材料不可避免地缺乏高机械性能和各向异性功能性能。因此,它们的进一步应用受到限制。受结构井井有条的生物软组织的启发,研究人员越来越多地研究高度有序的纳米复合水凝胶,将其作为具有独特的机械,光学和生物特性的功能性生物工程软材料。这些水凝胶在水凝胶网络基质中结合了长程有序纳米复合结构。在此,系统地审查了具有高度有序结构的纳米复合水凝胶的关键设计标准和最新的制备策略。然后,重点介绍了在软促动器,组织工程和传感器领域的最新应用进展。还讨论了高度有序的纳米复合水凝胶的未来发展和未来应用。系统地审查了具有高度有序结构的纳米复合水凝胶的关键设计标准和最新的制备策略。然后,重点介绍了在软促动器,组织工程和传感器领域的最新应用进展。还讨论了高度有序的纳米复合水凝胶的未来发展和未来应用。系统地审查了具有高度有序结构的纳米复合水凝胶的关键设计标准和最新的制备策略。然后,重点介绍了在软促动器,组织工程和传感器领域的最新应用进展。还讨论了高度有序的纳米复合水凝胶的未来发展和未来应用。
更新日期:2017-10-23
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