Generally, thermo-responsive hydrogels are prepared from thermo-responsive polymers like PNIPAM and its copolymers thereof. In this research, self-healable hydrogels with thermo-responsiveness and regulated cloud points (CPs) were prepared from water soluble P(N,N-dimethylacrylamide₉₈-stat-diacetone acrylamide₄₄) P(DMA₉₈-stat-DAA₄₄) through crosslinking induced thermo-responsiveness (CIT) mechanism. The P(DMA₉₈-stat-DAA₄₄) was crosslinked by PEO dihydrazide and DTDPH to regulate CP and mechanical property. The results showed that CP of the hydrogels with PEO₂₃ dihydrazide crosslinking almost keep intact with increasing crosslinking ratios because the phase transition depends mainly on the structure of the hydrophobic moiety. However, the hydrogels crosslinked by DTDPH change with crosslinking ratios because the size of resultant hydrophobic structure increases and tends to aggregate. The mechanical property and the CP of the hydrogels can be regulated by co-crosslinking. With DTDPH and PEO dihydrazide co-crosslinking, the CP can be regulated from below to above body temperature. Based on reversible acylhydrazone bond, the hydrogels also showed self-healing property.

通常，热响应性水凝胶由热响应性聚合物如PNIPAM及其共聚物制备。在此研究中，从水可溶性P制备的热响应性和调节浊点（CP）进行自我healable水凝胶（N，N-二甲基丙烯酰胺₉₈ - STAT -diacetone丙烯酰胺₄₄）P（DMA ₉₈ - STAT -DAA ₄₄）通过交联诱导的热响应性（CIT）机制。P（DMA ₉₈ - stat -DAA ₄₄）通过PEO二酰肼和DTDPH交联来调节CP和机械性能。结果表明，PEO ₂₃对水凝胶的CP二酰肼交联几乎随交联比率的增加而保持完整，因为相变主要取决于疏水部分的结构。然而，通过DTPDH交联的水凝胶随着交联率而改变，因为所得的疏水结构的尺寸增加并且趋于聚集。可以通过共交联来调节水凝胶的机械性能和CP。通过DTDPH和PEO二酰肼共交联，CP可以从体温从下到上调节。基于可逆的酰基hydr键，水凝胶还显示出自修复性能。