Differential ion mobility spectrometry (DMS) has emerged to be particularly well suited for the rapid and selective identification of gas phase ions at atmospheric pressure. DMS can overcome some limitations associated with mass spectrometry (MS) and conventional ion mobility spectrometry such as the use of vacuum systems. Miniaturization of DMS to the size of a palm portable device using state-of-art microelectromechanical systems significantly lowers power consumption, decreases analysis times (sub milliseconds) and reduces sample consumption. Microscale DMS can be used as both a standalone ion detector or coupled to MS and gas and liquid chromatography platforms to enable the detection of a wide range of chemical species in the field. Here, recent significant progress in the development and application of microscale DMS is comprehensively reviewed. The advantages, limitations, and future challenges for microscale DMS instrumentation for analytical, environmental, and bioanalytical chemistry applications are addressed.

中文翻译：

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微型差动离子淌度光谱仪，用于现场可部署的化学分析

差分离子迁移谱（DMS）特别适合于大气压下气相离子的快速和选择性鉴定。DMS可以克服与质谱法（MS）和常规离子迁移谱法相关的某些限制，例如使用真空系统。使用先进的微机电系统将DMS小型化为掌上便携式设备的大小，可显着降低功耗，减少分析时间（亚毫秒）并减少样品消耗。微型DMS既可以用作独立的离子检测器，也可以与MS以及气相色谱和液相色谱平台耦合使用，以实现对现场各种化学物种的检测。这里，全面回顾了微型DMS的开发和应用中最近的重大进展。解决了用于分析，环境和生物分析化学应用的微型DMS仪器的优点，局限性和未来的挑战。