With ever-increasing confidence, a substantial role for genetics in idiopathic pulmonary fibrosis (IPF), or at least in so-called sporadic IPF, has been established. As a result, some people advocate that the discovery of a known susceptibility single-nucleotide polymorphism (SNP) or other genetic marker in a patient with IPF should prompt removing the term idiopathic and replacing it with a more mechanism-based molecular classification.¹ And although this change is an attractive idea, some others still suggest that molecular subphenotyping of IPF really has no effect on the clinical management of patients.

中文翻译：

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IPF曼哈顿地块天际线中的另一栋建筑

随着信心的不断提高，遗传学已在特发性肺纤维化（IPF）或至少在所谓的散发性IPF中发挥了重要作用。结果，一些人主张在IPF患者中发现已知的易感性单核苷酸多态性（SNP）或其他遗传标记应促使删除特发性一词，并用更加基于机制的分子分类来代替它。¹尽管这种改变是一个吸引人的想法，但另一些人仍然认为IPF的分子亚表型确实对患者的临床管理没有影响。