Since their introduction in the 1940s and 1950s, pertussis vaccines (mostly in combination with diphtheria and tetanus toxoids as diphtheria, tetanus, and pertussis vaccines) have been very efficient in reducing pertussis mortality and morbidity in infants and young children. WHO estimates suggest that between 1999 and 2014, more than 100 000 infant deaths could have been averted mainly by increased coverage of pertussis vaccination.¹ Pertussis vaccines come in two varieties: one is made of whole-cell killed Bordetella pertussis cells, consequently called whole-cell pertussis vaccine, and the other is made from one to five purified and partly chemically inactivated bacterial virulence factors, consequently called acellular pertussis vaccine.

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脱细胞百日咳疫苗：去哪里？

自从1940年代和1950年代问世以来，百日咳疫苗（大多与白喉和破伤风类毒素一起用作白喉，破伤风和百日咳疫苗）在降低婴幼儿百日咳死亡率和发病率方面非常有效。世卫组织的估计表明，在1999年至2014年之间，本可以避免10万多例婴儿死亡，这主要是由于增加了百日咳疫苗的覆盖面。¹百日咳疫苗有两种：一种是由全细胞杀死的百日咳博德特氏菌细胞制成的，因此被称为全细胞百日咳疫苗；另一种是由一到五种纯化的且部分化学灭活的细菌致病因子制成的，因此被称为无细胞百日咳疫苗疫苗。