当前位置: X-MOL 学术Coord. Chem. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer.
Coordination Chemistry Reviews ( IF 20.3 ) Pub Date : 2017-10-21 , DOI: 10.1016/j.ccr.2017.09.007
Guangxu Lan 1 , Kaiyuan Ni 1 , Wenbin Lin 1
Affiliation  

Phototherapy involves the irradiation of tissues with light, and is commonly implemented in the forms of photodynamic therapy (PDT) and photothermal therapy (PTT). Photosensitizers (PSs) are often needed to improve the efficacy and selectivity of phototherapy via enhanced singlet oxygen generation in PDT and photothermal responses in PTT. In both cases, efficient and selective delivery of PSs to the diseased tissues is of paramount importance. Nanoscale metal-organic frameworks (nMOFs), a new class of hybrid materials built from metal connecting points and bridging ligands, have been examined as nanocarriers for drug delivery due to their compositional and structural tunability, highly porous structures, and good biocompatibility. This review summarizes recent advances on using nMOFs as nanoparticle PSs for applications in PDT and PTT.

中文翻译:


用于癌症光疗的纳米级金属有机框架。



光疗法涉及用光照射组织,通常以光动力疗法(PDT)和光热疗法(PTT)的形式实施。通常需要光敏剂 (PS) 通过增强 PDT 中的单线态氧生成和 PTT 中的光热反应来提高光疗的功效和选择性。在这两种情况下,将 PS 有效且选择性地递送至患病组织至关重要。纳米金属有机框架(nMOF)是一类由金属连接点和桥联配体构建的新型杂化材料,由于其成分和结构可调性、高度多孔结构和良好的生物相容性,已被作为药物输送的纳米载体进行了研究。本综述总结了使用 nMOF 作为纳米颗粒 PS 在 PDT 和 PTT 中应用的最新进展。
更新日期:2018-08-17
down
wechat
bug