Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of (Z)‐α‐Hydroxymethyl Allylic Sulfones,Advanced Synthesis & Catalysis

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Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of (Z)‐α‐Hydroxymethyl Allylic Sulfones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-11-06 , DOI: 10.1002/adsc.201701011
Yunlei Hou ₁ , Qi Shen ₁ , Zefei Li ₁ , Shaowei Chen ₁ , Yanfang Zhao ₁ , Mingze Qin ₁ , Ping Gong ₁

Affiliation

A novel method is reported for the stereoselective synthesis of highly functionalized allyl aryl sulfones. This protocol is based on a Pd‐catalyzed three‐component tandem reaction of sulfonyl hydrazides and aryl iodides with allenes and exhibits high (Z)‐selectivity, good yields, minimal waste, ample product scope, and operational simplicity.

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