Nanotechnology for Multimodal Synergistic Cancer Therapy,Chemical Reviews

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Nanotechnology for Multimodal Synergistic Cancer Therapy
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-10-19 00:00:00 , DOI: 10.1021/acs.chemrev.7b00258
Wenpei Fan _{1,

2,

3} , Bryant Yung ₃ , Peng Huang ₁ , Xiaoyuan Chen ₃

Affiliation

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential of treatment. Therefore, the current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, the cooperative enhancement interactions between several types of monotherapy contribute to the naissance of multimodal synergistic therapy, which results in remarkable superadditive (namely “1 + 1 > 2”) effects, stronger than any single therapy or their theoretical combination. In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergistic therapy as well as the intensive exploration of the underlying synergistic mechanisms for explaining the significant improvements in synergistic therapeutic outcome. Furthermore, the featured applications of multimodal synergistic therapy in overcoming tumor multidrug resistance, hypoxia, and metastasis will also be discussed in detail, which may provide new ways for the efficient regression and even elimination of drug resistant, hypoxic solid, or distant metastatic tumors. Finally, some design tips for multifunctional nanomaterials and an outlook on the future development of multimodal synergistic therapy will be provided, highlighting key scientific issues and technical challenges and requiring remediation to accelerate clinical translation.

中文翻译：

纳米技术用于多模式协同癌症治疗

肿瘤的复杂性，多样性和异质性严重破坏了治疗的治疗潜力。因此，当前临床研究的趋势已逐渐从专注于单一疗法转向结合疗法以提高治疗效果。更重要的是，几种单一疗法之间的协同增强相互作用促成了多峰协同疗法的兴起，这导致了显着的超加性（即“ 1 + 1> 2”）效应，比任何单一疗法或它们的理论组合都强。在这篇评论中，将系统地讨论有关纳米技术介导的多峰协同疗法的最新进展的最新研究，着重于构建用于实现双峰和三峰协同治疗的多功能纳米材料，以及对潜在的协同机制的深入探索，以解释协同治疗结果的显着改善。此外，还将详细讨论多峰协同疗法在克服肿瘤多药耐药性，缺氧和转移方面的特色应用，这可能为有效消退甚至消除耐药性，低氧实体瘤或远处转移性肿瘤提供新的途径。最后，将提供一些多功能纳米材料的设计技巧，以及对多峰协同疗法未来发展的展望，

更新日期：2017-10-19

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