Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-10-03 00:00:00 , DOI: 10.1039/c7bm00806f
Chunying Shi _{1,

2,

3,

4,

5} , Wei Chen _{6,

7,

8,

9,

10} , Bing Chen _{10,

11,

12,

13,

14} , Tao Shan _{1,

2,

3,

4,

5} , Weisheng Jia _{6,

7,

8,

9,

10} , Xianglin Hou _{10,

11,

12,

13,

14} , Longkun Li _{6,

7,

8,

9,

10} , Gang Ye _{6,

7,

8,

9,

10} , Jianwu Dai _{10,

11,

12,

13,

14}

Affiliation

Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (half of the entire bladder was resected). The results demonstrated that the functional biomaterials could promote bladder smooth muscle, vascular, and nerve regeneration and improve the function of neobladders. Thus, the CBD-bFGF/BAM functional scaffold may be a promising biomaterial for bladder reconstruction.

中文翻译：

在犬模型中使用载有胶原结合性bFGF的膀胱脱细胞基质进行膀胱再生

由于缺乏合适的再生支架，膀胱重建对于泌尿外科仍具有挑战性。在先前的研究中，我们使用了胶原结合的碱性成纤维细胞生长因子（CBD-bFGF）将bFGF结合到胶原支架上，这可以促进大鼠的膀胱再生。然而，在啮齿动物模型中有限的移植物大小不能提供足够的证据来证明该方法对人或大型动物的严重受损膀胱的修复能力。在这项研究中，使用CBD-bFGF激活膀胱脱细胞基质（BAM）支架，并在具有较大节段缺损（切除了整个膀胱的一半）的犬模型中评估了CBD-bFGF / BAM功能性支架。。结果表明，功能性生物材料可以促进膀胱平滑肌，血管，和神经再生，改善新膀胱的功能。因此，CBD-bFGF / BAM功能支架可能是用于膀胱重建的有前途的生物材料。

更新日期：2017-10-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11