Understanding the dynamics of acute viral infection is crucial for developing strategies to prevent and control infection. In this study, lentiviral dynamics in a host without adaptive immunity were examined in order to determine kinetic parameters of infection and quantify the effect of neutralizing antibodies in preventing infection, using mathematical modeling of data from equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Estimated parameters were used to calculate the basic reproductive number and virus doubling time and found that the rate that antibodies neutralized virus was ~18 times greater than the virus clearance rate. These results establish EIAV replication kinetics in SCID horses and the minimal efficacy of antibodies that blocked infection. Furthermore, they indicate that EIAV is at most mildly cytopathic. This study advances our understanding of EIAV infection and may have important implications for the control of other viral infections, including HIV.

了解急性病毒感染的动态对于制定预防和控制感染的策略至关重要。在这项研究中，使用马传染性贫血病毒（EIAV）感染马匹的数据的数学模型，研究了无适应性免疫的宿主中的慢病毒动力学，以确定感染的动力学参数并量化中和抗体在预防感染中的作用。严重的联合免疫缺陷症（SCID）。估计的参数用于计算基本繁殖数和病毒倍增时间，发现抗体中和病毒的速率约为病毒清除率的18倍。这些结果确定了SCID马匹的EIAV复制动力学以及阻断感染的抗体的最低功效。此外，他们表明EIAV最多是轻度的细胞病变。这项研究提高了我们对EIAV感染的理解，可能对控制包括HIV在内的其他病毒感染具有重要意义。