Modern biomedical imaging has revolutionized life science by providing anatomical, functional, and molecular information of biological species with high spatial resolution, deep penetration, enhanced temporal responsiveness, and improved chemical specificity. In recent years, these imaging techniques have been increasingly tailored for characterizing biomaterials and probing their interactions with biological tissues. This in turn has spurred substantial advances in engineering material properties to accommodate different imaging modalities that was previously unattainable. Here, we review advances in engineering both imaging modalities and material properties with improved contrast, providing a timely practical guide to better assess biomaterial–tissue interactions both in vitro and in vivo.

现代生物医学成像通过提供具有高空间分辨率、深度渗透、增强的时间响应性和改进的化学特异性的生物物种的解剖、功能和分子信息，彻底改变了生命科学。近年来，这些成像技术越来越多地用于表征生物材料并探测其与生物组织的相互作用。这反过来又刺激了工程材料性能的重大进步，以适应以前无法实现的不同成像模式。在这里，我们回顾了在改进对比度的成像模式和材料特性方面的进展，为更好地评估体外和体内生物材料与组织的相互作用提供了及时的实用指南。