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FUS Zigzags Its Way to Cross Beta.
Cell ( IF 45.5 ) Pub Date : 2017-Oct-19 , DOI: 10.1016/j.cell.2017.10.007
Alex S. Holehouse , Rohit V. Pappu

The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.

中文翻译:

FUS之字形穿越Beta版。

FUS蛋白的低复杂度域(LCD)形成浓度依赖性的组装体,包括液滴和基于原纤维的水凝胶。FUS在不同组装物中的分子结构及其功能相关性是引起激烈争论的主题。Murray等。报告了FUS LCD原纤维的原子级结构模型,该模型回答了一些问题并提出了新的问题。
更新日期:2017-10-19
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