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Friends in Low Places: Intestinal Commensals Limit Colitis through Molecular Mimicry.
Cell ( IF 45.5 ) Pub Date : 2017-Oct-19 , DOI: 10.1016/j.cell.2017.09.053
D. Garrett Brown , June L. Round

Inflammatory bowel disease is thought to arise from inappropriate inflammation to gut bacteria, yet mechanisms preventing these responses remain elusive. In this issue of Cell, Nanjundappa et al. report that Bacteroides share an epitope with a pancreas-specific peptide that induces protective CD8+ T cells, identifying molecular mimicry as a mechanism to enforce tolerance in the gut.

中文翻译:

低地的朋友:肠道共通通过分子模拟限制结肠炎。

人们认为炎症性肠病是由肠道细菌的不适当炎症引起的,但阻止这些反应的机制仍然难以捉摸。在《细胞》杂志上,Nanjundappa等人。报告称拟杆菌属与胰腺特异性肽共有一个表位,该肽诱导保护性CD8 + T细胞,并将分子拟态识别为增强肠道耐受性的机制。
更新日期:2017-10-19
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