Morphology Under Control: Engineering Biodegradable Stomatocytes,ACS Macro Letters

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Morphology Under Control: Engineering Biodegradable Stomatocytes
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-10-19 00:00:00 , DOI: 10.1021/acsmacrolett.7b00723
Imke A. B. Pijpers ₁ , Loai K. E. A. Abdelmohsen ₁ , David S. Williams _{1,

2} , Jan C. M. van Hest ₁

Affiliation

Biodegradable nanoarchitectures, with well-defined morphological features, are of great importance for nanomedical research; however, understanding (and thereby engineering) their formation is a substantial challenge. Herein, we uncover the supramolecular potential of PEG–PDLLA copolymers by exploring the physicochemical determinants that result in the transformation of spherical polymersomes into stomatocytes. To this end, we have engineered blended polymersomes (comprising copolymers with varying lengths of PEG), which undergo solvent-dependent reorganization inducing negative spontaneous membrane curvature. Under conditions of anisotropic solvent composition across the PDLLA membrane, facilitated by the dialysis methodology, we demonstrate osmotically induced stomatocyte formation as a consequence of changes in PEG solvation, inducing negative spontaneous membrane curvature. Controlled formation of unprecedented, biodegradable stomatocytes represents the unification of supramolecular engineering with the theoretical understanding of shape transformation phenomena.

中文翻译：

形态受到控制：可生物降解的工程造口细胞

具有良好形态特征的可生物降解的纳米结构对于纳米医学研究具有重要意义。但是，了解（从而进行工程设计）其形成是一个巨大的挑战。在这里，我们通过探索物理化学决定因素来揭示PEG-PDLLA共聚物的超分子潜力，这些决定因素会导致球形多聚体转化为造口细胞。为此，我们设计了混合聚合物囊泡（包含不同长度PEG的共聚物），它们经历了溶剂依赖性的重组，导致负的自发膜曲率。在透析方法促进整个PDLLA膜的各向异性溶剂组成的条件下，我们证明了渗透诱导的造口细胞形成是由于PEG溶剂化的变化，引起负的自发膜曲率。前所未有的，可生物降解的口腔细胞的受控形成代表了超分子工程学与形状转换现象的理论理解的统一。

更新日期：2017-10-19

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