Regulation of genome organization and gene expression by nuclear mechanotransduction

Nature Reviews Molecular Cell Biology, Published online: 18 October 2017; doi:10.1038/nrm.2017.101

Mechanical cues from the microenvironment can be efficiently transmitted to the nucleus to engage in the regulation of genome organization and gene expression. Recent technological and theoretical progress sheds new light on the relationships between cell mechanics, nuclear and chromosomal architecture and gene transcription.

中文翻译：

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核机械转导调控基因组组织和基因表达

核机械转导调控基因组组织和基因表达

Nature Reviews Molecular Cell Biology，在线发布：2017年10月18日; doi：10.1038 / nrm.2017.101

来自微环境的机械提示可以有效地传递到细胞核，参与基因组组织和基因表达的调控。最近的技术和理论进展为细胞力学，核和染色体结构与基因转录之间的关系提供了新的思路。