Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseases,Metallomics

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Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseases
Metallomics ( IF 2.9 ) Pub Date : 2017-06-09 00:00:00 , DOI: 10.1039/c7mt00066a
Ashima Bhattacharjee _{1,

2,

3,

4} , Kaustav Chakraborty _{1,

2,

3,

4} , Aditya Shukla _{1,

2,

3,

4}

Affiliation

Copper is a trace element essential for almost all living organisms. But the level of intracellular copper needs to be tightly regulated. Dysregulation of cellular copper homeostasis leading to various diseases demonstrates the importance of this tight regulation. Copper homeostasis is regulated not only within the cell but also within individual intracellular compartments. Inactivation of export machinery results in excess copper being redistributed into various intracellular organelles. Recent evidence suggests the involvement of glutathione in playing an important role in regulating copper entry and intracellular copper homeostasis. Therefore interplay of both homeostases might play an important role within the cell. Similar to copper, glutathione balance is tightly regulated within individual cellular compartments. This review explores the existing literature on the role of glutathione in regulating cellular copper homeostasis. On the one hand, interplay of glutathione and copper homeostasis performs an important role in normal physiological processes, for example neuronal differentiation. On the other hand, perturbation of the interplay might play a key role in the pathogenesis of copper homeostasis disorders.

中文翻译：

细胞铜稳态：与谷胱甘肽稳态相互作用的最新概念及其在生理和人类疾病中的意义

铜是几乎所有活生物体必不可少的微量元素。但是细胞内铜的水平需要严格调节。导致各种疾病的细胞铜稳态的失调证明了这种严格调控的重要性。铜稳态不仅在细胞内受到调节，而且在单个细胞内区室也受到调节。出口机械的失活导致多余的铜重新分配到各种细胞内细胞器中。最近的证据表明谷胱甘肽参与调节铜进入和细胞内铜稳态的重要作用。因此，两种稳态酶的相互作用可能在细胞内起重要作用。与铜类似，谷胱甘肽的平衡在各个细胞区室中受到严格调节。这篇综述探讨了谷胱甘肽在调节细胞铜稳态中的作用的现有文献。一方面，谷胱甘肽和铜稳态的相互作用在正常的生理过程例如神经元分化中起重要作用。另一方面，相互作用的干扰可能在铜稳态失调的发病机理中起关键作用。

更新日期：2017-06-09

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