In this study, a photoresist template with well-defined contact hole array was fabricated, to which radio frequency magnetron sputtering process was then applied to deposit an alloyed Zr₅₅Cu₃₀Al₁₀Ni₅ target, and finally resulted in ordered metallic glass nanotube (MGNT) arrays after removal of the photoresist template. The thickness of the MGNT walls increased from 98 to 126 nm upon increasing the deposition time from 225 to 675 s. The wall thickness of the MGNT arrays also increased while the dimensions of MGNT reduced under the same deposition condition. The MGNT could be filled with biomacromolecules to change the effective refractive index. The air fraction of the medium layer were evaluated through static water contact angle measurements and, thereby, the effective refractive indices the transverse magnetic (TM) and transverse electric (TE) polarized modes were calculated. A standard biotin–streptavidin affinity model was tested using the MGNT arrays and the fundamental response of the system was investigated. Results show that filling the MGNT with streptavidin altered the effective refractive index of the layer, the angle of reflectance and color changes identified by an L*a*b* color space and color circle on an a*b* chromaticity diagram. The limit of detection (LOD) of the MGNT arrays for detection of streptavidin was estimated as 25 nM, with a detection time of 10 min. Thus, the MGNT arrays may be used as a versatile platform for high-sensitive label-free optical biosensing.

在这项研究中，制造了具有明确接触孔阵列的光刻胶模板，然后对其进行了射频磁控溅射工艺以沉积合金化的Zr ₅₅ Cu ₃₀ Al ₁₀ Ni ₅去除光刻胶模板后，最终形成有序的金属玻璃纳米管（MGNT）阵列。随着沉积时间从225 s增加到675 s，MGNT壁的厚度从98 nm增加到126 nm。在相同的沉积条件下，MGNT阵列的壁厚也增加了，而MGNT的尺寸却减小了。MGNT可以填充生物大分子以改变有效折射率。通过静态水接触角测量来评估介质层的空气分数，从而计算出横向磁（TM）和横向电（TE）极化模式的有效折射率。使用MGNT阵列测试了标准的生物素-链霉亲和素亲和模型，并研究了系统的基本响应。结果表明，用抗生蛋白链菌素填充MGNT会改变层的有效折射率，反射角和颜色变化，这些变化由a * b *色度图上的L * a * b *颜色空间和色环标识。用于检测链霉亲和素的MGNT阵列的检测下限（LOD）估计为25 nM，检测时间为10分钟。因此，MGNT阵列可用作用于高灵敏度，无标签的光学生物传感的通用平台。