The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

中文翻译：

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精神分裂症在4322个人中存在广泛的白质微观结构差异：来自ENIGMA精神分裂症DTI工作组的结果。

精神分裂症中白质（WM）异常的区域分布仍然知之甚少，据报道，疾病对大脑的影响在不同研究之间差异很大。为了确定研究之间的共性，我们进行了我们认为是对精神分裂症中WM微结构差异的首次大规模协调研究。我们的分析包括来自29个独立国际研究的2359名健康对照和1963名精神分裂症患者；我们统一了跨站点的扩散张量成像（DTI）数据的处理和统计分析，并跨研究进行了荟萃分析的效果。精神分裂症患者的分数各向异性（FA）显着降低已广泛存在，并在代表所有主要WM筋膜的WM骨架内的25个感兴趣区域中的20个中检测到。效果大小因地区而异，整个WM骨骼在（d = 0.42）达到峰值，更多地受到外围区域的驱动，而不是定义了感兴趣区域的核心WM。前冠放射线（d = 0.40）和call体（d = 0.39），特别是其身体（d = 0.39）和属（d = 0.37）表现出最大的效果。在几乎所有分析区域中都观察到了较小程度的显着下降。与扩散测量相比，FA观察到更大的效应量。与对照组相比，精神分裂症患者的平均和径向扩散率明显更高。未发现精神分裂症发作时年龄或药物剂量的显着影响。作为迄今为止对精神疾病中WM差异的最大的协作分析，本研究提供了全世界精神分裂症患者广泛WM异常的可靠资料。