当前位置：
X-MOL 学术
›
RSC Med. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Applications and perspectives of nanomaterials in novel vaccine development
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7md00158d Yingbin Shen 1 , Tianyao Hao 1 , Shiyi Ou 1 , Churan Hu 1 , Long Chen 1
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7md00158d Yingbin Shen 1 , Tianyao Hao 1 , Shiyi Ou 1 , Churan Hu 1 , Long Chen 1
Affiliation
|
Vaccines show great potential for both prophylactic and therapeutic use in infections, cancer, and other diseases. With the rapid development of bio-technologies and materials sciences, nanomaterials are playing essential roles in novel vaccine formulations and can boost antigen effectiveness by operating as delivery systems to enhance antigen processing and/or as immune-potentiating adjuvants to induce or potentiate immune responses. The effect of nanoparticles in vaccinology showed enhanced antigen stability and immunogenicity as well as targeted delivery and slow release. However, obstacles remain due to the lack of fundamental knowledge on the detailed molecular working mechanism and in vivo bio-effects of nanoparticles. This review provides a broad overview of the current improvements in nanoparticles in vaccinology. Modern nanoparticle vaccines are classified by the nanoparticles' action based on either delivery system or immune potentiator approaches. The mechanisms of interaction of nanoparticles with the antigens and the immune system are discussed. Nanoparticle vaccines approved for use are also listed. A fundamental understanding of the in vivo bio-distribution and the fate of nanoparticles will accelerate the rational design of new nanoparticles comprising vaccines in the future.
中文翻译：
纳米材料在新型疫苗研发中的应用与展望
疫苗在感染、癌症和其他疾病的预防和治疗方面显示出巨大的潜力。随着生物技术和材料科学的快速发展，纳米材料在新型疫苗配方中发挥着重要作用，并且可以通过作为递送系统来增强抗原加工和/或作为免疫增强佐剂来诱导或增强免疫反应来提高抗原有效性。纳米粒子在疫苗学中的作用显示出增强的抗原稳定性和免疫原性以及靶向递送和缓慢释放。然而，由于缺乏对纳米颗粒详细分子工作机制和体内生物效应的基础知识，仍然存在障碍。这篇综述对目前疫苗学中纳米颗粒的改进提供了广泛的概述。现代纳米颗粒疫苗根据纳米颗粒基于递送系统或免疫增强剂方法的作用进行分类。讨论了纳米粒子与抗原和免疫系统相互作用的机制。还列出了批准使用的纳米颗粒疫苗。对纳米颗粒体内生物分布和命运的基本了解将加速未来包含疫苗的新型纳米颗粒的合理设计。
更新日期：2017-10-17
中文翻译：
纳米材料在新型疫苗研发中的应用与展望
疫苗在感染、癌症和其他疾病的预防和治疗方面显示出巨大的潜力。随着生物技术和材料科学的快速发展，纳米材料在新型疫苗配方中发挥着重要作用，并且可以通过作为递送系统来增强抗原加工和/或作为免疫增强佐剂来诱导或增强免疫反应来提高抗原有效性。纳米粒子在疫苗学中的作用显示出增强的抗原稳定性和免疫原性以及靶向递送和缓慢释放。然而，由于缺乏对纳米颗粒详细分子工作机制和体内生物效应的基础知识，仍然存在障碍。这篇综述对目前疫苗学中纳米颗粒的改进提供了广泛的概述。现代纳米颗粒疫苗根据纳米颗粒基于递送系统或免疫增强剂方法的作用进行分类。讨论了纳米粒子与抗原和免疫系统相互作用的机制。还列出了批准使用的纳米颗粒疫苗。对纳米颗粒体内生物分布和命运的基本了解将加速未来包含疫苗的新型纳米颗粒的合理设计。
京公网安备 11010802027423号