Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma,ACS Chemical Neuroscience

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Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1021/acschemneuro.7b00286
Yan Li ₁ , Marisa Lafontaine ₁ , Susan Chang ₂ , Sarah J. Nelson _{1,

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Affiliation

Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) is a powerful non-invasive tool for characterizing spatial variations in metabolic profiles for patients with glioma. Metabolic parameters obtained using this technique have been shown to predict treatment response, disease progression, and transformation to a more malignant phenotype. The availability of ultra-high-field MR systems has the potential to improve the characterization of metabolites. The purpose of this study was to compare the metabolite profiles acquired with conventional long echo time (TE) MRSI at 3T with those obtained with short TE MRSI at 3T and 7T in patients with glioma. The data acquisition parameters were optimized separately for each echo time and field strength to obtain volumetric coverage within clinically feasible data acquisition times of 5–10 min. While a higher field strength did provide better detection of metabolites with overlapping peaks, spatial coverage was reduced and the use of inversion recovery to reduce lipid precluded the detection of lipid in regions of necrosis. For serial evaluation of large, heterogeneous lesions, the use of 3T short TE MRSI may thus be preferred. Despite the limited number of metabolites that it is able to detect, the use of 3T long TE MRSI gives the best contrast in choline/N-acetyl aspartate between normal appearing brain and tumor and also allows the separate detection of lactate and lipid. It may therefore be preferred for serial evaluation of patients with high-grade glioma and for detection of malignant transformation in patients with low-grade glioma.

中文翻译：

3T和7T短时和长时回波磁共振成像在评估脑胶质瘤患者脑代谢物中的比较

三维质子磁共振波谱成像（MRSI）是一种功能强大的非侵入性工具，可用于表征神经胶质瘤患者代谢谱中的空间变化。已显示使用该技术获得的代谢参数可预测治疗反应，疾病进展以及向更恶性表型的转化。超高场MR系统的可用性具有改善代谢产物表征的潜力。这项研究的目的是比较在3T时使用传统的长回声时间（TE）MRSI与在3T和7T时使用短TE MRSI所获得的代谢物谱。分别针对每个回波时间和场强对数据采集参数进行了优化，以在5-10分钟的临床可行数据采集时间内获得体积覆盖。虽然较高的场强确实可以更好地检测出峰重叠的代谢物，但空间覆盖率却降低了，并且使用反向回收来减少脂质的方法排除了在坏死区域中检测脂质的可能性。对于大型，异质性病变的连续评估，因此可能首选使用3T短TE MRSI。尽管能够检测到的代谢物数量有限，但使用3T长的TE MRSI可以在胆碱/ 空间覆盖率降低，并且使用反转恢复降低脂质的方法排除了坏死区域脂质的检测。对于大型，异质性病变的连续评估，因此可能首选使用3T短TE MRSI。尽管能够检测到的代谢物数量有限，但使用3T长的TE MRSI可以在胆碱/ 空间覆盖率降低，并且使用反转恢复降低脂质的方法排除了坏死区域脂质的检测。对于大型，异质性病变的连续评估，因此可能首选使用3T短TE MRSI。尽管能够检测到的代谢物数量有限，但使用3T长的TE MRSI可以在胆碱/正常出现的大脑和肿瘤之间的N-乙酰天门冬氨酸，还可以单独检测乳酸和脂质。因此，对于高级别神经胶质瘤患者的系列评估以及对于低级别神经胶质瘤患者的恶性转化检测，它可能是首选。

更新日期：2017-10-16

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