Crystallization-Based Isolation of Pure Rutin from Herbal Extract of Sophora japonica L.,Organic Process Research & Development

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Crystallization-Based Isolation of Pure Rutin from Herbal Extract of Sophora japonica L.
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1021/acs.oprd.7b00247
Elena Horosanskaia ₁ , Tan Minh Nguyen ₂ , Tien Dinh Vu ₂ , Andreas Seidel-Morgenstern ₁ , Heike Lorenz ₁

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Crystallization-based isolation of rutin from a plant extract of Sophora japonica L. was studied. Solid−liquid phase equilibria of rutin were determined in methanol, ethanol, and 2-propanol. Solvate formation and phase stability were investigated using X-ray powder diffraction and thermogravimetric analysis coupled with differential scanning calorimetry. The experiments revealed short-term stability of rutin ethanolate at ambient conditions in contrast to the rutin trihydrate phase, which was found to be stable. On the basis of the particular solubility behavior of both solvate phases in ethanol, a seeded crystallization process in batch and semicontinuous operation mode was designed and successfully performed. Crystalline rutin trihydrate of 99% purity was isolated with overall process yields of 95 and 87% in the batch and semicontinuous processes, respectively. Because of their cost-efficiency and robustness, the purification processes are attractive to be applied directly in countries where the plants are growing.

中文翻译：

基于结晶的苦参提取物中纯芦丁的分离。

从植物提取物芦丁的基于结晶隔离国槐研究了L.。在甲醇，乙醇和2-丙醇中测定了芦丁的固液相平衡。使用X射线粉末衍射和热重分析结合差示扫描量热法研究了溶剂合物的形成和相稳定性。实验揭示了芦丁乙醇化物在环境条件下的短期稳定性，与芦丁三水合相相反，后者被认为是稳定的。根据两个溶剂化物相在乙醇中的特殊溶解性行为，设计并成功进行了分批和半连续操作模式的晶种结晶过程。分离出纯度为99％的结晶芦丁三水合物，分批和半连续工艺的总工艺收率分别为95％和87％。由于它们具有成本效益和稳健性，

更新日期：2017-10-17

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