Abstract We report the synthesis and characterization of a myeloperoxidase (MPO)-responsive, biodegradable, and luminescent material derived from functionalized cyclodextrin. The nanoparticle based on this functional material shows notably high and sustainable luminescent signals upon triggering by inflammatory conditions with abnormally elevated reactive oxygen species and MPO. Activated neutrophils during inflammatory responses can be selectively imaged using this nanoprobe, with luminescent signals positively correlated to neutrophil counts. This nanoprobe enables in vivo precise quantification and tracking of the number and dynamics of neutrophils in both superficial and deep tissues in various mouse models of inflammatory diseases, including peritonitis, paw edema, colitis, and acute lung injury. In vitro and in vivo evaluations also demonstrate the safety and biocompatibility of this newly engineered material in its native and nanoparticle forms.

中文翻译：

---

用于炎症性疾病实时成像的髓过氧化物酶反应性和可生物降解的发光材料

摘要 我们报告了一种髓过氧化物酶 (MPO) 响应性、可生物降解和发光材料的合成和表征，该材料源自功能化环糊精。基于这种功能材料的纳米颗粒在被炎症条件触发时显示出显着高且可持续的发光信号，活性氧和 MPO 异常升高。炎症反应期间激活的中性粒细胞可以使用这种纳米探针进行选择性成像，发光信号与中性粒细胞计数呈正相关。这种纳米探针能够在体内精确量化和跟踪各种炎症疾病小鼠模型中浅表和深部组织中中性粒细胞的数量和动态，包括腹膜炎、爪子水肿、结肠炎和急性肺损伤。