Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums†,Reaction Chemistry & Engineering

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Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1039/c7re00142h
Aiichiro Nagaki _{1,

2,

3,

4,

5} , Satoshi Ishiuchi _{1,

2,

3,

4,

5} , Keita Imai _{1,

2,

3,

4,

5} , Kengo Sasatsuki _{1,

2,

3,

4,

5} , Yuichi Nakahara _{5,

6,

7,

8,

9} , Jun-ichi Yoshida _{1,

2,

3,

4,

5}

Affiliation

Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Extremely fast micromixing is responsible for high chemoselectivity.

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