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Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1039/c7re00142h
Aiichiro Nagaki 1, 2, 3, 4, 5 , Satoshi Ishiuchi 1, 2, 3, 4, 5 , Keita Imai 1, 2, 3, 4, 5 , Kengo Sasatsuki 1, 2, 3, 4, 5 , Yuichi Nakahara 5, 6, 7, 8, 9 , Jun-ichi Yoshida 1, 2, 3, 4, 5
Affiliation  

Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Extremely fast micromixing is responsible for high chemoselectivity.

中文翻译:

微混合使双官能亲电试剂与官能芳基锂发生化学选择性反应

使用配备有微型混合器的流动微反应器系统,可以成功生成高度不稳定的功能性芳基锂,然后与双功能亲电试剂进行化学选择性反应,从而得到高度功能化的化合物而无需保护官能团。极快的微量混合可实现高化学选择性。
更新日期:2017-10-16
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