As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

作为一种创新的非抗生素方法，在400-470 nm光谱中的抗菌蓝光已证明其固有的抗菌特性，这是由于病原微生物中存在内源性光敏发色团所致，因此有望作为抗生素抗性的抵消剂。自从我们在2012年发布抗菌蓝光的最新评论以来，该领域已有大量新研究报道。在这里，我们提供了过去5年中新研究发现的最新概述，包括不同微生物的抗菌蓝光灭活的功效，其作用机理，抗菌蓝光与其他蚂蚁的协同作用，对宿主细胞的影响和组织，微生物对抗菌蓝光产生抗性的潜在发展，以及抗菌蓝光的新型间隙递送方法。还讨论了抗菌蓝光的潜在新应用。