Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene,Organic Process Research & Development

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Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-10-13 00:00:00 , DOI: 10.1021/acs.oprd.7b00291
Zhenghui Wen _{1,

2} , Fengjun Jiao ₁ , Mei Yang ₁ , Shuainan Zhao _{1,

2} , Feng Zhou _{1,

2} , Guangwen Chen ₁

Affiliation

In this work, continuous flow nitration of trifluoromethoxybenzene (TFMB) was conducted in a microchannel reactor. The effects of process parameters, including temperature, residence time, sulfuric acid strength, flow rate, and reactor structure, were systemically investigated. It was found that the aforementioned process parameters had significant effect on TFMB conversion, while the product selectivity was merely sensitive to the reaction temperature. On the basis of the results of process parameter optimization, a scale-up strategy combining microreactor with distributed packed tubular reactor was presented. Consequently, excellent performance was achieved in the combined reactor with a kilogram-scale production.

中文翻译：

三氟甲氧基苯连续流硝化的工艺开发和规模化

在这项工作中，在微通道反应器中进行了三氟甲氧基苯（TFMB）的连续流硝化。系统地研究了工艺参数的影响，包括温度，停留时间，硫酸强度，流速和反应器结构。发现上述工艺参数对TFMB转化具有显着影响，而产物选择性仅对反应温度敏感。在工艺参数优化结果的基础上，提出了一种将微反应器与分布式填充管式反应器相结合的放大策略。因此，在具有千克规模生产的组合反应器中获得了优异的性能。

更新日期：2017-10-14

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