Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in the context of various neurological diseases. The high prevalence of fatigue as either a symptom or a comorbidity of neurological disease must be taken seriously, as fatigue interferes with patients' activities of daily living, has a remarkable negative impact on quality of life, and is a major reason for early retirement. The tremendous consequences of fatigue are consistent across neurological diseases, as is the uncertainty concerning its underlying pathophysiological mechanisms. Inconsistencies in defining fatigue contribute to the present situation, in which fatigue represents one of the least-studied and least- understood conditions. Tools for assessing fatigue abound, but few can be recommended for clinical or research use. To make matters worse, evidence-based pharmacological treatment options are scarce. However, non-pharmacological approaches are currently promising and likely to become of increasing importance. In sum, fatigue is challenging for both health-care professionals and patients. The present article aims to provide a comprehensive review of the literature on fatigue in neurological disease, and to reveal its complexity, as well as weaknesses in the concept of fatigue itself.

疲劳，最能描述为压倒性的疲倦和疲惫感，是在各种神经系统疾病的背景下发生的。由于疲劳会干扰患者的日常生活，对生活质量产生显着的负面影响，并且是提早退休的主要原因，因此必须高度重视将疲劳作为一种神经系统疾病的症状或合并症的高患病率。疲劳的巨大后果在神经系统疾病中是一致的，关于其潜在病理生理机制的不确定性也是一致的。定义疲劳的不一致导致了当前状况，其中疲劳代表了研究最少和了解最少的状况之一。评估疲劳的工具比比皆是，但很少推荐用于临床或研究用途。去把事情弄得更糟，循证药物治疗的选择很少。然而，非药物学方法目前是有希望的，并且可能变得越来越重要。总而言之，疲劳对于医疗保健专业人员和患者都具有挑战性。本文旨在提供有关神经系统疾病疲劳的文献的全面综述，并揭示其复杂性以及疲劳概念本身的弱点。