Surface plasmon resonance imaging (SPRi) has more and more applications in the fields of biology and life sciences due to its unique features of label-free and high-throughput detection and workability in physiological conditions, but it is suffering from insufficient sensitivity, especially in detecting the small molecules or low level of substances. Various methods have since been developed to improve its sensitivity, but it lacks of summary except for their working principles, setups and applications. This review is thus designed to summary the sensitivity-oriented research progresses, covering signal enhancement and/or amplification, and noise and background suppression, with chemistry-enhancing strategies as focus and non-chemistry as supplement. A brief prospect in near future is also given.

中文翻译：

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对表面等离振子共振成像灵敏度研究进展的批判性评论

表面等离振子共振成像（SPRi）由于其无标记和高通量检测的独特特征以及在生理条件下的可操作性而在生物学和生命科学领域中得到越来越多的应用，但其灵敏度不足，尤其是在检测小分子或低水平​​的物质。此后已经开发出各种方法来提高其灵敏度，但是除了它们的工作原理，设置和应用之外，它没有摘要。因此，本综述旨在总结以灵敏度为导向的研究进展，涵盖信号增强和/或放大，噪声和背景抑制，并以化学增强策略为重点，以非化学为补充。在不久的将来也有一个简短的展望。